AHS18

What makes us think that ketogenic diets will pay off in treatment of prevention of cancer? Our evolutionary past was more variable and less regular than today and ketone bodies were surely a food of our ancestors. The Warburg effect, simply understood as reliance of cancers on glycolysis (non-aerobic) even in the presence of oxygen, may be more dynamic process for coping with changing environment and we want to know where ketone bodies fit in. In this, we want to understand how caloric restriction, the only firmly established treatment or prevention of cancer, bears on de facto or explicit inclusion of carbohydrate restriction. Perhaps most elusive, we want to understand the effect of reactive oxygen species.