AHS18

Elevated circulating insulin or hyperinsulinemia is commonly observed in insulin resistant individuals. It is a compensatory mechanism to maintain normal blood glucose levels when cells become less responsive to insulin. Despite the observed normal blood glucose in some individuals, hyperinsulinemia remains an independent risk factor for various chronic diseases including type 2 diabetes, cardiovascular disease, cancers and neurological disorders. While circulating insulin can be measured as an important disease biomarker, it is not typically tested in the clinical practice, even in the context of prediabetes and type 2 diabetes risk screening. Interventions that aim to prevent and manage chronic diseases must involve normalizing insulin as well as blood glucose.